Assessment of fibrinogen, high sensitive C-reactive protein (hsCRP) and homocysteine in type 2 diabetes mellitus under treatment

Keywords: Type 2 diabetes mellitus (T2DM) high sensitive C-reactive protein (hsCRP) Homocysteine (HCY) cardiovascular disease (CVD). Introduction: Incidence of vascular complications is found to be high in type 2 diabetes mellitus patients. Conventional risk factors were not able to explain this high prevalence of CAD. Since inflammation is considered as one of the major reasons for vascular complications, markers like plasma fibrinogen, hsCRP and homocysteine may be used to analyze the risk. Aim & Objective: To assess the cardiovascular risk by measuring fibrinogen, hsCRP and homocysteine in T2DM subjects under treatment. Materials & Methods: 40 T2DM subjects under treatment and 40 healthy sex matched subjects of 40-60yrs were included in the study. Plasma Fibrinogen, serum hsCRP and HCY were measured by kit method.Result & discussion: In our study, plasma fibrinogen level (697.44±84.23) and hsCRP level (1.79±1.31) were significantly increased in T2DM subjects when compared to controls (156.75±103.19, 0.55±0.44) with p value less than 0.05. Conclusion: Increased plasma fibrinogen and hsCRP were observed in T2DM subjects compared to healthy subjects. No significant difference was observed in HCY levels among the study groups. Evaluation of these parameters along with regular blood sugar may be helpful for early prediction of cardiovascular disease.